Company Directory / Organox Limited

Business Description

"Designed by transplant surgeons, for transplant surgeons. Living Organs For Life. Transforming transplantation with the OrganOx metra ex vivo normothermic liver perfusion device.

OrganOx Limited was founded in 2008, as a spin-out from the UNIVERSITY OF OXFORD, to exploit normothermic preservation technology invented by Prof Peter Friend and colleagues and further developed by Prof Constantin Coussios at the University.

Since that time, the core technology has been developed into the OrganOx metra, a revolutionary device for storing livers at normal body temperatures for extended periods of time. Following extensive pre-clinical studies and the successful completion of clinical studies, the product is now commercially available within the EU.

A further pivotal clinical study comparing 220 transplanted livers with static cold storage has recently been completed at 7 leading liver transplant centres in Europe and initial results presented at 2 major congresses. The final trial data are now being prepared for publication.

OrganOx is currently engaged in a further pivotal study in the US and a further study at the Queen Elizabeth Hospital, Birmingham to test the viability and transplant potential of marginal livers.

Conventional cold preservation involves storage of the liver at 4˚C, using a non-physiological perfusion solution that aims to minimise liver decay. By contrast, warm preservation seeks to re-create an environment that mimics the human body by continuously perfusing at physiological pressures and flows with oxygen-carrying red cells at 37˚C and providing nutrition. The liver is therefore functional during the preservation period, producing bile, metabolizing glucose and maintaining a physiological pH. This enables objective assessment of organ performance prior to transplant, extended preservation times, and the potential use of organs that are presently being discarded."

Registered Address

9400 Garsington Road
Oxford Business Park

Contact Details

Key Data

4535 Medical Equipment
Company Number
Private Limited Company
Company Age
11 years
April 7, 2008
Nature of Business
72190 - Other research and experimental development on natural sciences and engineering
Year End
April 30
Accounts Due
January 31, 2020
Latest Accounts
April 30, 2018